Analysis Tools
immune system
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• increased numbers of T and B cells
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• Th1 response in spleen and cervical lymph nodes indicated by IFN gamma and IL17 staining
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• eventually develop splenomegaly
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• memory or activated T cells increase in cervical lymph nodes
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• eventually develop lymphadenopathy
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• extra orbital lacrimal glands are inflamed
• periductal infiltration of CD4+ T cells and B cells
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• splenocytes show a defective proliferative response to lipopolysaccharide but not to CD40, Il4 or anti-IgM
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• elevated serum immune globulins
• high titers of antinuclear antibodies
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• in vivo production of Il12 impaired
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• impaired production in macrophages but in vivo levels near normal
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• prolonged TNF alpha production
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• at 12 weeks of age mice develop spontaneous inflammation of the ocular surface unlike in wild-type mice
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blepharitis
(
J:96363
)
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• at 4 weeks of age, mice exhibit infiltration of inflammatory cells into the conjunctival epithelia
• at 14 weeks of age, mice exhibit heavy inflammatory cell infiltration in the submucosal areas of the conjunctiva
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• at 14 weeks of age, mice exhibit moderate infiltration of the corneal limbus
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• often present in aged mice
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• atopic dermatitis-like skin lesions in some mice at 4-5 weeks of age, in all mice by 10 weeks
(J:91297)
• mostly in the periocular region initially
(J:194832)
• eventually spreads over the whole face with skin erosion and hair loss
(J:194832)
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• dermatitis mostly in the periocular region initially
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vision/eye
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• increased apoptosis
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eyelid edema
(
J:194832
)
|
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks
|
|
• extra orbital lacrimal glands are inflamed
• periductal infiltration of CD4+ T cells and B cells
|
|
• at 12 weeks of age mice develop spontaneous inflammation of the ocular surface unlike in wild-type mice
|
blepharitis
(
J:96363
)
|
• at 4 weeks of age, mice exhibit infiltration of inflammatory cells into the conjunctival epithelia
• at 14 weeks of age, mice exhibit heavy inflammatory cell infiltration in the submucosal areas of the conjunctiva
|
|
• at 14 weeks of age, mice exhibit moderate infiltration of the corneal limbus
|
|
• lymphocyte infiltration and loss of goblet cells in the submucosa of the conjunctival epithelium
|
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• at 4 weeks, mild loss of goblet cells is observed in the conjunctival epithelia
• at 14 weeks, mice exhibit degeneration and loss of goblet cells in the conjunctival epithelia of both the palpebral and bulbar conjunctiva
|
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• reduced tear secretion
|
integument
|
• atopic dermatitis-like skin lesions in some mice at 4-5 weeks of age, in all mice by 10 weeks
(J:91297)
• mostly in the periocular region initially
(J:194832)
• eventually spreads over the whole face with skin erosion and hair loss
(J:194832)
|
|
• dermatitis mostly in the periocular region initially
|
skin lesions
(
J:96363
)
|
• some mice develop dermatitis-like skin lesions
|
homeostasis/metabolism
eyelid edema
(
J:194832
)
|
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks
|
endocrine/exocrine glands
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• increased apoptosis
|
|
• extra orbital lacrimal glands are inflamed
• periductal infiltration of CD4+ T cells and B cells
|
hematopoietic system
|
• eventually develop splenomegaly
|
|
• increased numbers of T and B cells
|
|
• Th1 response in spleen and cervical lymph nodes indicated by IFN gamma and IL17 staining
|
|
• splenocytes show a defective proliferative response to lipopolysaccharide but not to CD40, Il4 or anti-IgM
|
|
• elevated serum immune globulins
• high titers of antinuclear antibodies
|
respiratory system
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• often present in aged mice
|
cellular
|
• increased apoptosis
|
growth/size/body
eyelid edema
(
J:194832
)
|
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks
|
|
• eventually develop splenomegaly
|
craniofacial
eyelid edema
(
J:194832
)
|
• swelling as early as 2 weeks of age
• inflammatory effects in all mice by 8 weeks
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Stevens-Johnson syndrome | DOID:0050426 | J:96363 | ||
