About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3046834
Allelic
Composition
Cdkn1atm1(HBsAg)Xya/Cdkn1a+
Genetic
Background
either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1atm1(HBsAg)Xya mutation (0 available); any Cdkn1a mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

liver/biliary system
• observed in some mice
• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age
• no metastases were detected
• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout
• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
J:88078


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory