Phenotypes Associated with This Genotype

Genotype
MGI:3046422

• Allelic Composition: Lrp5^tm1Jfh/Lrp5⁺; Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91055 )

• development arrested prior to E10.5

• mice die by E18

embryo

abnormal developmental patterning ( J:91055 )

• embryonic development normal until gastrulation

• posterior portion of the embryo sometimes remains undifferentiated

abnormal primitive streak formation ( J:91055 )

• failure of some nascent mesoderm to migrate properly from the primitive streak

absent somites ( J:91055 )

• no visible somites

abnormal extraembryonic tissue morphology ( J:91055 )

abnormal amnion morphology ( J:91055 )

• by E7.5 an abnormal accumulation of cells protrudes into the amniotic cavity

nervous system

increased forebrain size ( J:91055 )

• greatly enlarged by E7.5

• posterior regions of the brain not affected