Phenotypes Associated with This Genotype

Genotype
MGI:3045440

• Allelic Composition: Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz; Tg(Camk2a-cre)2Gsc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:89842 )

• following injections of kainic acid (an excitotoxin) mutant mice carrying the transgene display decreased survival compared to mutant mice not carrying the transgene

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:89842 )

• following injections of kainic acid (an excitotoxin) mutant mice carrying the transgene display more severe seizures compared to mutant mice not carrying the transgene

• seizure severity did not differ between mutant mice carrying the transgene and null mice homozygous for Cnr1^tm1.1Ltz

nervous system

increased susceptibility to pharmacologically induced seizures ( J:89842 )

• following injections of kainic acid (an excitotoxin) mutant mice carrying the transgene display more severe seizures compared to mutant mice not carrying the transgene

• seizure severity did not differ between mutant mice carrying the transgene and null mice homozygous for Cnr1^tm1.1Ltz

increased susceptibility to neuronal excitotoxicity ( J:89842 )

• kainic acid treated mutant mice carrying the transgene have significantly more apoptosis in the CA1 and CA3 regions of the hippocampus compared to mutant mice not carrying the transgene

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:89842 )

• kainic acid treated mutant mice carrying the transgene have significantly more apoptosis in the CA1 and CA3 regions of the hippocampus compared to mutant mice not carrying the transgene

increased susceptibility to xenobiotic induced morbidity/mortality ( J:89842 )

• following injections of kainic acid (an excitotoxin) mutant mice carrying the transgene display decreased survival compared to mutant mice not carrying the transgene

cellular

increased susceptibility to neuronal excitotoxicity ( J:89842 )

• kainic acid treated mutant mice carrying the transgene have significantly more apoptosis in the CA1 and CA3 regions of the hippocampus compared to mutant mice not carrying the transgene