Mouse Genome Informatics
hm
    Wfs1tm1Yoka/Wfs1tm1Yoka
B6.Cg-Wfs1tm1Yoka
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
endocrine/exocrine glands
• the number of beta cells decreases with age in homozygous mice probably as a result of increased beta cell susceptibility to apoptosis
• this effect is more prominent on a [(129/Sv x C57BL/6) x C57BL/6]F2 background than on a C57BL/6 background
• insulin content in islets is decreased by 16% compared to wild-type islets
• glucose stimulated insulin secretion normalized to insulin content is decreased 23% compared to wild-type mice
• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

homeostasis/metabolism
• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age
• plasma insulin concentrations are reduced by 50% in homozygous mice at 36 weeks of age but no difference in plasma insulin concentrations are seen at 24 weeks of age
• blood glucose levels are significantly higher 15 and 30 minutes into an oral glucose tolerance test
• at 17 weeks of age increase in plasma insulin concentrations in response to glucose load are decreased

Mouse Models of Human Disease
OMIM IDRef(s)
Wolfram Syndrome 1; WFS1 222300 J:90420