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Phenotypes Associated with This Genotype
Genotype
MGI:3044706
Allelic
Composition
Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic
Background
B6.Cg-Wfs1tm1Yoka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wfs1tm1Yoka mutation (0 available); any Wfs1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the number of beta cells decreases with age in homozygous mice probably as a result of increased beta cell susceptibility to apoptosis
• this effect is more prominent on a [(129/Sv x C57BL/6) x C57BL/6]F2 background than on a C57BL/6 background
• insulin content in islets is decreased by 16% compared to wild-type islets
• glucose stimulated insulin secretion normalized to insulin content is decreased 23% compared to wild-type mice
• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age

homeostasis/metabolism
• glucagon positive cells and pancreatic glucagon content are increased in homozygous mice at 36 weeks of age
• plasma insulin concentrations are reduced by 50% in homozygous mice at 36 weeks of age but no difference in plasma insulin concentrations are seen at 24 weeks of age
• blood glucose levels are significantly higher 15 and 30 minutes into an oral glucose tolerance test
• at 17 weeks of age increase in plasma insulin concentrations in response to glucose load are decreased

Mouse Models of Human Disease
OMIM ID Ref(s)
Wolfram Syndrome 1; WFS1 222300 J:90420


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory