Phenotypes Associated with This Genotype

Genotype
MGI:3044566

• Allelic Composition: Kras^tm4.1Tyj/Kras⁺
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89333 )

• no viable embryos are found after E11.5

cardiovascular system

enlarged heart ( J:89333 )

• at E9.5 mutant embryos display cardiomegaly

embryo

decreased embryo size ( J:89333 )

• mutant embryos are small

abnormal embryonic neuroepithelium morphology ( J:89333 )

• neuroepithelial sections have extensive areas of architectural distortion and apoptosis

growth/size/body

enlarged heart ( J:89333 )

• at E9.5 mutant embryos display cardiomegaly

decreased embryo size ( J:89333 )

• mutant embryos are small

nervous system

increased embryonic neuroepithelium apoptosis ( J:89333 )

• neuroepithelial sections have extensive areas of apoptosis

abnormal embryonic neuroepithelium morphology ( J:89333 )

• neuroepithelial sections have extensive areas of architectural distortion and apoptosis

abnormal brain development ( J:89333 )

• at E9.5 mutant embryos display abnormal brain development

integument

pallor ( J:89333 )

• mutant embryos are pale

cellular

increased embryonic neuroepithelium apoptosis ( J:89333 )

• neuroepithelial sections have extensive areas of apoptosis