Mouse Genome Informatics
hm
    MitfMi-wh/MitfMi-wh
involves: C57BL * DBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

MitfMi-wh/+ and MitfMi-wh/MitfMi-wh and control

pigmentation
• coat color is indistinguishable from that of Tyrc homozygotes (J:13058)
• the coat is entirely lacking pigment (J:125080)
• eyes are pink and pigmentless
• little or no pigment in the iris

vision/eye
• eyes are pink and pigmentless
• little or no pigment in the iris
• eye size appears reduced compared to f Tyrc homozygotes (J:13058)
• the eyes are only mildly reduced in size (J:125080)

growth/size/body
• reduced body size compared to f Tyrc homozygotes

reproductive system
• litter size is reduced in homozygous female to homozygous male crosses

hearing/vestibular/ear
• no section of the cochlear duct was ever found to be normal
• abnormal in its entirety
• the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

nervous system

integument
• coat color is indistinguishable from that of Tyrc homozygotes (J:13058)
• the coat is entirely lacking pigment (J:125080)

Mouse Models of Human Disease
OMIM IDRef(s)
Albinism, Ocular, with Sensorineural Deafness 103470 J:13058
Tietz Syndrome 103500 J:13058
Waardenburg Syndrome, Type 2A; WS2A 193510 J:13058