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Phenotypes Associated with This Genotype
Genotype
MGI:3044413
Allelic
Composition
MitfMi-wh/MitfMi-wh
Genetic
Background
involves: C57BL * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (11 available); any Mitf mutation (56 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

MitfMi-wh/+ and MitfMi-wh/MitfMi-wh and control

pigmentation
• coat color is indistinguishable from that of Tyrc homozygotes (J:13058)
• the coat is entirely lacking pigment (J:125080)
• eyes are pink and pigmentless
• little or no pigment in the iris

vision/eye
• eyes are pink and pigmentless
• little or no pigment in the iris
• eye size appears reduced compared to f Tyrc homozygotes (J:13058)
• the eyes are only mildly reduced in size (J:125080)

growth/size/body
• reduced body size compared to f Tyrc homozygotes

reproductive system
• litter size is reduced in homozygous female to homozygous male crosses

hearing/vestibular/ear
• no section of the cochlear duct was ever found to be normal
• abnormal in its entirety
• the majority of ears show dedifferentiation and cellular migrations in the cochlear duct and the saccule

nervous system

integument
• coat color is indistinguishable from that of Tyrc homozygotes (J:13058)
• the coat is entirely lacking pigment (J:125080)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory