Phenotypes Associated with This Genotype

Genotype
MGI:3043697

• Allelic Composition: Ercc5^tm1Shm/Ercc5^tm1Shm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89911 )

• homozygous mutants die by P23 before weaning

• the average lifespan for homozygous mutants is 9 - 10 days shorter than that of Ercc5^tm3Shm homozygotes

digestive/alimentary system

abnormal small intestine morphology ( J:89911 )

• undeveloped small intestines are seen in homozygous mutants

growth/size/body

postnatal growth retardation ( J:89911 )

• homozygous mice exhibit growth failure

• the average body weight for homozygous mutants is slightly less than that of Ercc5^tm3Shm homozygotes

homeostasis/metabolism

phototoxicity ( J:89911 )

• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice

• UV induced DNA lesions are not removed in homozygous mutant cell

integument

phototoxicity ( J:89911 )

• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice

• UV induced DNA lesions are not removed in homozygous mutant cell