Mouse Genome Informatics
hm
    Ercc5tm3Shm/Ercc5tm3Shm
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• most (22 out of 24) of the homozygous mutants die within 30 days of birth with none surviving beyond P139
• the average lifespan for homozygous mutants is 9 - 10 days longer than that of Ercc5tm1Shm homozygotes

digestive/alimentary system
• undeveloped small intestines are seen in homozygous mutants

growth/size
• all homozygous mice exhibit growth failure
• the average body weight for homozygous mutants is slightly greater than that of Ercc5tm1Shm homozygotes

homeostasis/metabolism
• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice and as sensitive as cells from Ercc5tm1Shm
• UV induced DNA lesions are not removed in homozygous mutant cell

integument
• cells from homozygous mutants are more sensitive to UV light than cells from wild-type mice and as sensitive as cells from Ercc5tm1Shm
• UV induced DNA lesions are not removed in homozygous mutant cell

Mouse Models of Human Disease
OMIM IDRef(s)
Xeroderma Pigmentosum, Complementation Group G; XPG 278780 J:89911