Phenotypes Associated with This Genotype

Genotype
MGI:3043478

• Allelic Composition: Ptpn22^tm1Achn/Ptpn22^tm1Achn
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

enlarged spleen ( J:90029 )

• homozygous mice older than 6 months develop enlarged spleens

increased B cell number ( J:90029 )

• associated with the increased germinal center formation is an increase in GL-7+ B cells and CD23+ follicular B cells

increased follicular B cell number ( J:90029 )

• an increase in CD23+ follicular B cells is seen

increased spleen germinal center number ( J:90029 )

• homozygous mice display increased numbers of large, well-formed germinal centers compared to wild-type mice

• no evidence of autoimmune-mediated organ damage is seen despite the spontaneous formation of germinal centers

increased IgE level ( J:90029 )

• serum levels of IgE are increased in homozygotes compared to wild-type mice

increased IgG1 level ( J:90029 )

• associated with the increased germinal center formation is an increase IgG1+ foci

• serum levels of IgG1 are increased in homozygotes compared to wild-type mice

increased IgG2a level ( J:90029 )

• serum levels of IgG2a are increased in homozygotes compared to wild-type mice

abnormal T cell physiology ( J:90029 )

• following antigen stimulation increased development of CD4+ and CD8+ T cells is seen in homozygotes

• 3 - 4 days after T cell receptor activation CD4+ and CD8+ T cells display increased cell cycling, enhanced proliferation, and increased cytokine production compared to T cells from wild-type mice

• negative selection of T cells is unaffected in homozygous mice

immune system

enlarged spleen ( J:90029 )

• homozygous mice older than 6 months develop enlarged spleens

increased B cell number ( J:90029 )

• associated with the increased germinal center formation is an increase in GL-7+ B cells and CD23+ follicular B cells

increased follicular B cell number ( J:90029 )

• an increase in CD23+ follicular B cells is seen

increased spleen germinal center number ( J:90029 )

• homozygous mice display increased numbers of large, well-formed germinal centers compared to wild-type mice

• no evidence of autoimmune-mediated organ damage is seen despite the spontaneous formation of germinal centers

increased IgE level ( J:90029 )

• serum levels of IgE are increased in homozygotes compared to wild-type mice

increased IgG1 level ( J:90029 )

• associated with the increased germinal center formation is an increase IgG1+ foci

• serum levels of IgG1 are increased in homozygotes compared to wild-type mice

increased IgG2a level ( J:90029 )

• serum levels of IgG2a are increased in homozygotes compared to wild-type mice

abnormal T cell physiology ( J:90029 )

• following antigen stimulation increased development of CD4+ and CD8+ T cells is seen in homozygotes

• 3 - 4 days after T cell receptor activation CD4+ and CD8+ T cells display increased cell cycling, enhanced proliferation, and increased cytokine production compared to T cells from wild-type mice

• negative selection of T cells is unaffected in homozygous mice

abnormal Peyer's patch germinal center morphology ( J:90029 )

• homozygous mice display increased numbers of large, well-formed germinal centers compared to wild-type mice

• no evidence of autoimmune-mediated organ damage is seen despite the spontaneous formation off germinal centers

enlarged lymph nodes ( J:90029 )

• homozygous mice older than 6 months develop enlarged lymph nodes

growth/size/body

enlarged spleen ( J:90029 )

• homozygous mice older than 6 months develop enlarged spleens