Mouse Genome Informatics
hm
    Rps6ka3tm1.1Kry/Rps6ka3tm1.1Kry
involves: 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
craniofacial
• widened due to reduced cranial bones (J:89403)
• open at birth (J:89403)
• reduced size observed at E16 and at birth (J:89403)
• reduced size observed at E16 and at birth (J:89403)
• reduced size observed at E16 and at birth (J:89403)

skeleton
• widened due to reduced cranial bones (J:89403)
• open at birth (J:89403)
• reduced size observed at E16 and at birth (J:89403)
• reduced size observed at E16 and at birth (J:89403)
• reduced size observed at E16 and at birth (J:89403)
• reduced long bone length at 1 month of age (J:89403)
• marked reduction in bone mass of vertebrae at 1 and 2 months of age (J:89403)
• marked reduction in bone mass of long bones at 1 and 2 months of age (J:89403)
• decreased bone formation rate, indicative of impaired osteoblast function (J:89403)
• normal number and function of osteoclasts (J:89403)
• delay of skull mineralization observed at E16 and at birth (J:89403)

endocrine/exocrine glands
N
• no defects detected by histological analysis of the salivary, mammary, pancreas, pituitary, thyroid, or adrenal glands (J:89403)

hearing/vestibular/ear
N
• no defects detected by histological analysis of the ear (J:89403)

hematopoietic system
N
• no defects detected by histological analysis of the bone marrow (J:89403)

immune system
N
• no defects detected by histological analysis of the thymus, spleen, or lymph nodes (J:89403)

digestive/alimentary system
N
• no defects detected by histological analysis of the esophagus, stomach, duodenum, ileum, or colon (J:89403)

liver/biliary system
N
• no defects detected by histological analysis of the liver (J:89403)

muscle
N
• no defects detected by histological analysis of striated muscle (J:89403)

renal/urinary system
N
• no defects detected by histological analysis of the kidney or urinary bladder (J:89403)

reproductive system
N
• no defects detected by histological analysis of the ovary, oviducts, uterus, or vagina (J:89403)

respiratory system
N
• no defects detected by histological analysis of the nose, trachea, lung, or pleura (J:89403)

cardiovascular system
N
• no defects detected by histological analysis of the heart or the aorta (J:89403)

taste/olfaction
N
• no defects detected by histological analysis of the olfactory mucosa and tongue (J:89403)

vision/eye
N
• no defects detected by histological analysis of the eye (J:89403)

nervous system
N
• no defects detected by histological analysis of the cerebral cortex, hippocampus, basal ganglia, cerebellum, or brain stem (J:89403)

integument
N
• no defects detected by histological analysis of the skin (J:89403)

Mouse Models of Human Disease
OMIM IDRef(s)
Coffin-Lowry Syndrome; CLS 303600 J:89403