Phenotypes Associated with This Genotype

Genotype
MGI:3043042

• Allelic Composition: Epo^tm1Jae/Epo^tm1Jae
• Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:29254 )

• death occurs between E13 and E15

embryo

abnormal placenta morphology ( J:29254 )

• although placenta size was normal, there were few erythrocytes present

hematopoietic system

abnormal erythropoiesis ( J:29254 )

• no erythropoietic islands found in fetal liver

• proerythroblasts and yolk sac derived erythrocytes found

• CFU-E progenitors decreased from E12.5 to E13.5

anemia ( J:29254 )

• embryos have severe anemia

• blood cell numbers reduced 5-10 fold

increased erythroid progenitor cell number ( J:29254 )

• increased numbers of CFU-E and BFU-E progenitors present

liver/biliary system

increased hepatocyte apoptosis ( J:29254 )

• many pyknotic nuclei found (apoptosis)

small liver ( J:29254 )

• fetal liver 4-5 fold smaller than normal

pale liver ( J:29254 )

cellular

increased hepatocyte apoptosis ( J:29254 )

• many pyknotic nuclei found (apoptosis)