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Phenotypes Associated with This Genotype
Genotype
MGI:3042846
Allelic
Composition		 Tlr7tm1Flv/Tlr7tm1Flv
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr7tm1Flv mutation (1 available); any Tlr7 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased circulating interferon-alpha level ( J:89257 )
• while IFNalpha secretion in response to infection with vesicular stomatitis virus (a ssRNA virus) was similar to controls, serum levels of IFNalpha were reduced after infection relative to controls

homeostasis/metabolism
decreased circulating interferon-alpha level ( J:89257 )
• while IFNalpha secretion in response to infection with vesicular stomatitis virus (a ssRNA virus) was similar to controls, serum levels of IFNalpha were reduced after infection relative to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory