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Phenotypes Associated with This Genotype
Genotype
MGI:3042606
Allelic
Composition
Prop1df/Prop1df
Genetic
Background
STOCK Prop1df
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prop1df mutation (2 available); any Prop1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
N
• testes nearly normal
• pituitary gland lacked identifiable somatotropes
• reduced numbers of thyrotropic hormone producing cells
• anterior pituitary reduced in size
• follicles were small and some tissue was not organized into follicles
• large follicles absent

growth/size/body
• daily i.p. injections of bovine growth hormone for ~ 6 weeks produced animals of nearly normal size

homeostasis/metabolism
• males, in the pituitary
• males
• treatment with ovine prolactin or prolactin producing grafts, resulted in increased FSH levels
• males, in the pituitary

reproductive system
• large follicles absent
• still infertile after treatment with bovine growth hormone
• became fertile after treatment with bovine growth hormone

nervous system
• pituitary gland lacked identifiable somatotropes
• reduced numbers of thyrotropic hormone producing cells
• anterior pituitary reduced in size

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypopituitarism DOID:9406 OMIM:221750
OMIM:262600
OMIM:262700
OMIM:613038
OMIM:613986
J:5900 , J:6340 , J:7211 , J:12169 , J:36967


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory