Phenotypes Associated with This Genotype

Genotype
MGI:3042181

• Allelic Composition: Amhr2^tm1Bhr/Amhr2^tm1Bhr
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal Sertoli cell morphology ( J:36027 )

♂ • observed in areas of focal seminiferous tubule degeneration

seminiferous tubule degeneration ( J:36027 )

♂ • focal atrophy of the germinal epithelium by 2 months of age

increased Leydig cell number ( J:36027 )

♂ • observed in areas of focal seminiferous tubule degeneration

reproductive system

reproductive system phenotype ( J:36027 )

♀N • female mice developed, exhibited normal folliculogenesis and germ cell development, and were fertile

abnormal Sertoli cell morphology ( J:36027 )

♂ • observed in areas of focal seminiferous tubule degeneration

seminiferous tubule degeneration ( J:36027 )

♂ • focal atrophy of the germinal epithelium by 2 months of age

increased Leydig cell number ( J:36027 )

♂ • observed in areas of focal seminiferous tubule degeneration

male pseudohermaphroditism ( J:36027 )

♂ • males developed Mullerian duct derivatives, including a uterus, oviducts, and a partial vagina that were superimposed upon the male reproductive system

♂ • male mice had testes of normal size that were properly descended into the scrotal sac

♂ • normal differentiation of male-specific Wolffian duct-derived tissue

secondary sex reversal ( J:36027 )

male infertility ( J:36027 )

♂ • spermatogenesis was unimpaired and sperm was produced, however some males were infertile due to the presence of female reproductive organs that blocked sperm transfer

reduced male fertility ( J:36027 )

♂ • some male mice sired offspring, however fewer litters relative to controls