Phenotypes Associated with This Genotype

Genotype
MGI:3042180

• Allelic Composition: Prkcz^tm1Jmos/Prkcz^tm1Jmos
• Genetic Background: involves: 129P2/OlaHsd * 129/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B cell number ( J:72720 )

• reduced relative percentage of B cells in peripheral and mesenteric lymph nodes at 2 weeks

• lymph nodes enriched in precursor (B220low, IgM-) B cells

• alterations in relative percentages decreased with age

decreased spleen B cell follicle size ( J:72720 )

• smaller B cell follicles, evident at 2 weeks of age, but less apparent at 4 weeks and normal at 7 to 8 weeks

abnormal spleen marginal zone morphology ( J:72720 )

• evident at 2 weeks of age, but less apparent at 4 weeks and normal at 7 to 8 weeks

immune system

immune system phenotype ( J:72720 )

N • normal thymus

decreased B cell number ( J:72720 )

• alterations in relative percentages decreased with age

• reduced relative percentage of B cells in peripheral and mesenteric lymph nodes at 2 weeks

• lymph nodes enriched in precursor (B220low, IgM-) B cells

decreased spleen B cell follicle size ( J:72720 )

• smaller B cell follicles, evident at 2 weeks of age, but less apparent at 4 weeks and normal at 7 to 8 weeks

abnormal spleen marginal zone morphology ( J:72720 )

• evident at 2 weeks of age, but less apparent at 4 weeks and normal at 7 to 8 weeks

abnormal Peyer's patch morphology ( J:72720 )

• impaired segregation between B and T cell zones, evident at 2 weeks of age

abnormal Peyer's patch follicle morphology ( J:72720 )

• reduced number and size of follicles, evident at 2 weeks of age, still apparent at 4 weeks, with normal number of reduced size follicles at 7 to 8 weeks

small Peyer's patches ( J:72720 )

• evident at 2 weeks of age