Mouse Genome Informatics
hm
    Pomctm1Sora/Pomctm1Sora
involves: 129S2/SvHsd * 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
pigmentation
• lighter ventral coat color than that of wild-type

behavior/neurological

growth/size
• increased body weight, relative to controls, when on standard lab diet (4.5% fat)
• significantly higher fat and lean tissue mass relative to controls
• attenuated affect on both food intake and weight loss in response to leptin; observed in older, obese, mice but not in younger, nonobese mice
• responses to both acute anoretic and chronic administration of peptide-YY3-36 were similar to those of wild-type
• a high fat diet augmented the obese phenotype

homeostasis/metabolism
• a high fat diet augmented the obese phenotype
• corticosterone was undetectable
• while oxygen consumption was increased in absolute terms, when corrected for total body mass, resting oxygen consumption was reduced relative to controls

integument
• lighter ventral coat color than that of wild-type

Mouse Models of Human Disease
OMIM IDRef(s)
Obesity 601665 J:89244