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Phenotypes Associated with This Genotype
Genotype
MGI:3041643
Allelic
Composition
Pomctm1Sora/Pomctm1Sora
Genetic
Background
involves: 129S2/SvHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pomctm1Sora mutation (0 available); any Pomc mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• lighter ventral coat color than that of wild-type

behavior/neurological

growth/size/body
• increased body weight, relative to controls, when on standard lab diet (4.5% fat)
• significantly higher fat and lean tissue mass relative to controls
• attenuated affect on both food intake and weight loss in response to leptin; observed in older, obese, mice but not in younger, nonobese mice
• responses to both acute anoretic and chronic administration of peptide-YY3-36 were similar to those of wild-type
• a high fat diet augmented the obese phenotype

homeostasis/metabolism
• a high fat diet augmented the obese phenotype
• corticosterone was undetectable
• while oxygen consumption was increased in absolute terms, when corrected for total body mass, resting oxygen consumption was reduced relative to controls

integument
• lighter ventral coat color than that of wild-type

Mouse Models of Human Disease
OMIM ID Ref(s)
Obesity 601665 J:89244


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory