Phenotypes Associated with This Genotype

Genotype
MGI:3040994

• Allelic Composition: Tfap2c^tm1.1Hsc/Tfap2c^tm1.1Hsc
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:78934 )

• embryos die between E7 and E9

embryo

decreased embryo size ( J:78934 )

• mutant embryos display significant growth retardation by E7.5 (50-fold smaller than wild-type)

absent mesoderm ( J:78934 )

• mesoderm is not formed; likely due to gastrulation defects

abnormal trophoblast giant cell morphology ( J:78934 )

• in culture, epithelial cell morphology was not maintained over time

decreased trophoblast giant cell number ( J:78934 )

• fewer giant cells were present

small ectoplacental cone ( J:78934 )

• trophoblast cells in the ectoplacental cone did not proliferate

absent placental labyrinth ( J:78934 )

• the labyrinth layer failed to form

growth/size/body

decreased embryo size ( J:78934 )

• mutant embryos display significant growth retardation by E7.5 (50-fold smaller than wild-type)