Phenotypes Associated with This Genotype

Genotype
MGI:3040300

• Allelic Composition: Rgs9^tm1Citb/Rgs9^tm1Citb
• Genetic Background: either: 129S1/Sv-Rgs9^tm1Citb or (involves: 129S1/Sv * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:60188 )

N • homozygotes displayed normal retinal morphology up to 8 months of age

N • mutant retinas contained normal amounts of other photoreceptor proteins

abnormal eye physiology ( J:60188 )

• mutant photoreceptors displayed abnormally retarded recovery of their light responses and slowed rates of GTP hydrolysis by transducin relative to wild-type controls

• the mutation had no effect on the activation of the G-protein cascade, but significantly prolonged its deactivation and interfered with the speeding of incremental dim flashes during light adaptation

abnormal rod electrophysiology ( J:60188 )

• mutant rods exhibited extremely slowed photoresponses, recovering from moderate intensity flashes with a dominant time constant (9 s) that is 45-fold longer than that in wild-type mice (0.2 s)