mortality/aging
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice
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cellular
• following mitomycine C treatment, mice exhibit a small reduction in the frequency of sister chromatid exchange compared with similarly treated wild-type mice
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• mice were sensitive to DNA crosslinking agents and to ionizing radiation
• there was no affect on somatic instability
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• derived ES cells show a 2-3X increase in sensitivity to ionizing radiation
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hematopoietic system
• following treatment with X-rays, mice exhibit a small hematopoietic depression unlike similarly treated wild-type mice
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immune system
N |
• mice were specifically examined for an effect on V(D)J recombination and none was found
• at the same time, no other gross abnormalities were observed
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homeostasis/metabolism
• following treatment with mitomycine C, mice exhibit increased lethality compared with similarly treated wild-type mice
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