Phenotypes Associated with This Genotype

Genotype
MGI:3039429

• Allelic Composition: Sox10^tm1Weg/Sox10^tm1Weg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon fasciculation ( J:203636 )

• defasciculation of olfactory, vemeronasal, and terminal nerves

abnormal axon guidance ( J:203636 )

• olfactory, vomeronasal, and terminal nerves form, however axons are abnormally routed at E14.5; some do not target the olfactory bulb and instead contact axons from the other side, dorsally to the nasal septum

abnormal olfactory bulb morphology ( J:203636 )

• abnormal colonization of the olfactory bulbs by olfactory ensheathing cells at E14.5

• at E12.5, the migratory mass has already formed, however defective colonization of the olfactory-bulb anlage by olfactory ensheathing cells is seen on more rostral sections

• disorganization of the olfactory nerve layer of the olfactory bulbs

abnormal glial cell morphology ( J:203636 )

• almost complete absence of olfactory ensheathing cells in the nasal mesenchyme and along the nerve pathway and only a few are seen in the upper part of the frontonasal mesenchyme, under the migratory mass

• numerous olfactory ensheathing cells are present in the migratory mass and the olfactory nerve layer, but they appear to encircle the olfactory bulbs incompletely, forming a thinner, disorganized, and discontinuous layer

abnormal axon morphology ( J:203636 )

• axons of olfactory, vemeronasal, and terminal nerves are not ensheathed along their most ventral trajectory

cellular

abnormal axon fasciculation ( J:203636 )

• defasciculation of olfactory, vemeronasal, and terminal nerves

abnormal axon guidance ( J:203636 )

• olfactory, vomeronasal, and terminal nerves form, however axons are abnormally routed at E14.5; some do not target the olfactory bulb and instead contact axons from the other side, dorsally to the nasal septum

decreased cell migration ( J:203636 )

• gonadotropin-releasing hormone cells accumulate on the vomeronasal and terminal nerve trajectories in the nasal mesenchyme in E14.5 mutants unlike in controls in which the cells are migrating at this time within the two cerebral hemispheres, indicating impaired migration

embryo

abnormal frontonasal mesenchyme morphology ( J:203636 )

• absence of olfactory ensheathing cells in most of the nasal mesenchyme is already seen at E12.5

• gonadotropin-releasing hormone cells accumulate on the vomeronasal and terminal nerve trajectories in the nasal mesenchyme in E14.5 mutants unlike in controls in which gonadotropin-releasing hormone cells are migrating at this time within the two cerebral hemispheres

growth/size/body

abnormal frontonasal mesenchyme morphology ( J:203636 )

• absence of olfactory ensheathing cells in most of the nasal mesenchyme is already seen at E12.5

• gonadotropin-releasing hormone cells accumulate on the vomeronasal and terminal nerve trajectories in the nasal mesenchyme in E14.5 mutants unlike in controls in which gonadotropin-releasing hormone cells are migrating at this time within the two cerebral hemispheres

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Kallmann syndrome		DOID:3614		J:203636