Phenotypes Associated with This Genotype

Genotype
MGI:3039414

• Allelic Composition: Foxo1^tm1Whb/Foxo1^tm1Whb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:88638 )

• homozygotes die by E10.5

cardiovascular system

abnormal internal carotid artery morphology ( J:88638 )

• at E9.5 the branches of the internal carotid artery appear malformed

abnormal intersomitic vessel morphology ( J:88638 )

• at E9.5 the intersomitic vessels are abnormal compared to wild-type mice

absent vitelline blood vessels ( J:88638 )

• at E9.5 yolk sacs from homozygotes lacked blood vessels

delayed heart looping ( J:88638 )

• cardiac looping is retarded in homozygotes at E9.5

distended pericardium ( J:88638 )

• the pericardium distended in homozygotes at E9.5

embryo

absent vitelline blood vessels ( J:88638 )

• at E9.5 yolk sacs from homozygotes lacked blood vessels