Phenotypes Associated with This Genotype

Genotype
MGI:3038826

• Allelic Composition: Psme3^tm1Jjm/Psme3^tm1Jjm
• Genetic Background: B6.129X1-Psme3^tm1Jjm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle checkpoint function ( J:88626 )

• mutant embryonic fibroblasts show a reduced number of actively mitotic cells in either the S or G₂/M phase

decreased fibroblast proliferation ( J:88626 )

• mutant embryonic fibroblasts show a reduced growth rate and lower saturation density

growth/size/body

postnatal growth retardation ( J:88626 )

• after weaning mutants gain weight at a reduced rate while maintaining constant organ to body mass ratios

hematopoietic system

decreased double-positive T cell number ( J:88626 )

• spleen T cell and B cell percentages are normal but CD4⁺/CD8⁺ ratios are elevated due to a slight but significant reduction in CD3⁺CD8⁺ T cells

immune system

decreased double-positive T cell number ( J:88626 )

• spleen T cell and B cell percentages are normal but CD4⁺/CD8⁺ ratios are elevated due to a slight but significant reduction in CD3⁺CD8⁺ T cells

increased susceptibility to fungal infection ( J:88626 )

• clearance of fungal infection is delayed in mutants compared to wild-type mice

• following fungal infection the proportion of CD3⁺ and CD8⁺ T cells in the spleen is significantly reduced

• response to mitogens and viral infection is normal