Phenotypes Associated with This Genotype

Genotype
MGI:3038707

• Allelic Composition: Ror1^tm1Ymi/Ror1^tm1Ymi; Ror2^tm1Ymi/Ror2^tm1Ymi
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:72948 )

• most double homozygotes were dead at birth

cardiovascular system

transposition of great arteries ( J:72948 )

• complete transposition of the great arteries

ventricular septal defect ( J:72948 )

skeleton

abnormal long bone morphology ( J:72948 )

• dysplasia of both distal and proximal long bones

absent sternum ( J:72948 )

• sternal agenesis

abnormal pubic symphysis morphology ( J:72948 )

• dysplasia of the pubic symphysis

abnormal cartilage morphology ( J:72948 )

abnormal cartilage development ( J:72948 )

• shortened longitudinal columns of proliferative chondrocytes

abnormal chondrocyte morphology ( J:72948 )

• reduced numbers of small flattened chondrocytes