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Phenotypes Associated with This Genotype
Genotype
MGI:3038368
Allelic
Composition
Rorbtm1Mba/Rorbtm1Mba
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rorbtm1Mba mutation (0 available); any Rorb mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• in spite of a grossly abnormal retina, homozygous mice remain entrained to the prevailing light/dark cycle
• reluctant to explore in a new environment
• more docile than littermate controls
• hind paw grasping reflex when suspended by their tail
• gain muscular strength with age
• often fall over and roll when first beginning to walk
• develop a peculiar "duck-like" gait with age
• although generally fertile, males do not breed successfully for the first six months

growth/size/body
• homozygotes are undersized

vision/eye
• severely malformed
• disorganized and lacking the normal layer structure
• made up of significantly fewer cells
• retinal degeneration apparently begins shortly after birth
• little visual activity in the retino-cortical pathway

nervous system
N
• no gross anatomical changes in brain


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory