behavior/neurological
N |
• in spite of a grossly abnormal retina, homozygous mice remain entrained to the prevailing light/dark cycle
|
• reluctant to explore in a new environment
|
• more docile than littermate controls
|
limb grasping
(
J:48923
)
• hind paw grasping reflex when suspended by their tail
|
• gain muscular strength with age
• often fall over and roll when first beginning to walk
|
abnormal gait
(
J:48923
)
• develop a peculiar "duck-like" gait with age
|
• although generally fertile, males do not breed successfully for the first six months
|
growth/size/body
• homozygotes are undersized
|
vision/eye
• severely malformed
|
• disorganized and lacking the normal layer structure
• made up of significantly fewer cells
|
• retinal degeneration apparently begins shortly after birth
|
• little visual activity in the retino-cortical pathway
|
nervous system
N |
• no gross anatomical changes in brain
|