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Phenotypes Associated with This Genotype
Genotype
MGI:3038333
Allelic
Composition
Rp1tm1Jnz/Rp1tm1Jnz
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Progressive degeneration of photoreceptors of Rp1tm1Jnz/Rp1tm1Jnz mice

vision/eye
• optic nerve pallor and smaller retinal blood vessels (J:76071)
• optic nerve pallor and smaller retinal blood vessels (J:76071)
• abnormalities are found in both rods and cones (J:76071)
• abnormalities are found in both rods and cones (J:76071)
• after 21 days of age there is a significant drop in the number of photoreceptors (J:76071)
• reduced by 50% by 3 months of age (J:76071)
• apoptosis levels are higher among photoreceptors (J:76071)
• after 21 days of age there is a significant drop in the number of photoreceptors (J:76071)
• reduced by 50% by 3 months of age (J:76071)
• apoptosis levels are higher among photoreceptors (J:76071)
• length of outer segment normal until about 25 days of age after which progressive degeneration begins; by 9 months, the length is negligible (J:76071)
• discs and whorls in the outer segment are variable in size and lack correct orientation; by 9 months few discs and whorls remain (J:76071)
• length of outer segment normal until about 25 days of age after which progressive degeneration begins; by 9 months, the length is negligible (J:76071)
• discs and whorls in the outer segment are variable in size and lack correct orientation; by 9 months few discs and whorls remain (J:76071)
• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments (J:109781)
• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments (J:109781)
• cone degeneration takes place more slowly than in rods, not significant before 10 months of age (J:76071)
• cone degeneration takes place more slowly than in rods, not significant before 10 months of age (J:76071)
• progressive dysfunction of rods and cones begins at around 2 months and continues throughout the first year of life (J:76071)
• progressive dysfunction of rods and cones begins at around 2 months and continues throughout the first year of life (J:76071)
• single photon response amplitude is elevated 1.6-fold compared to controls (J:151463)
• time to peak to single-photon stimulus is 1.2 fold longer than controls (J:151463)
• amplitudes of saturating responses are significantly decreased by 45% (J:151463)
• single photon response amplitude is elevated 1.6-fold compared to controls (J:151463)
• time to peak to single-photon stimulus is 1.2 fold longer than controls (J:151463)
• amplitudes of saturating responses are significantly decreased by 45% (J:151463)

nervous system
• abnormalities are found in both rods and cones (J:76071)
• abnormalities are found in both rods and cones (J:76071)
• after 21 days of age there is a significant drop in the number of photoreceptors (J:76071)
• reduced by 50% by 3 months of age (J:76071)
• apoptosis levels are higher among photoreceptors (J:76071)
• after 21 days of age there is a significant drop in the number of photoreceptors (J:76071)
• reduced by 50% by 3 months of age (J:76071)
• apoptosis levels are higher among photoreceptors (J:76071)
• length of outer segment normal until about 25 days of age after which progressive degeneration begins; by 9 months, the length is negligible (J:76071)
• discs and whorls in the outer segment are variable in size and lack correct orientation; by 9 months few discs and whorls remain (J:76071)
• length of outer segment normal until about 25 days of age after which progressive degeneration begins; by 9 months, the length is negligible (J:76071)
• discs and whorls in the outer segment are variable in size and lack correct orientation; by 9 months few discs and whorls remain (J:76071)
• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments (J:109781)
• accumulation of short stacks of enlarged disoriented discs in place of organized outer segments (J:109781)
• cone degeneration takes place more slowly than in rods, not significant before 10 months of age (J:76071)
• cone degeneration takes place more slowly than in rods, not significant before 10 months of age (J:76071)

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinitis Pigmentosa 1; RP1 180100 J:76071


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory