Mouse Genome Informatics
hm
    GckRgsc702/GckRgsc702
involves: C57BL/6J * DBA/2J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• homozygotes die within 1 week of birth

growth/size/body
• by P2 homozygotes are obviously growth retarded

homeostasis/metabolism
• hyperglycemia is apparent by P2
• blood glucose levels exceed 600 mg/dl by P4
• histological analysis reveals reduced liver glycogen levels
• at P1-2 marked glucosuria is seen

liver/biliary system
• the liver is markedly steatotic by P4
• histological analysis reveals enlarged fat droplets in hepatocytes

renal/urinary system
• at P1-2 marked glucosuria is seen

Mouse Models of Human Disease
OMIM IDRef(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919