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Phenotypes Associated with This Genotype
Genotype
MGI:3038222
Allelic
Composition
GckRgsc702/GckRgsc702
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
GckRgsc702 mutation (1 available); any Gck mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die within 1 week of birth

growth/size/body
• by P2 homozygotes are obviously growth retarded

homeostasis/metabolism
• hyperglycemia is apparent by P2
• blood glucose levels exceed 600 mg/dl by P4
• histological analysis reveals reduced liver glycogen levels
• at P1-2 marked glucosuria is seen

liver/biliary system
• the liver is markedly steatotic by P4
• histological analysis reveals enlarged fat droplets in hepatocytes

renal/urinary system
• at P1-2 marked glucosuria is seen

Mouse Models of Human Disease
OMIM ID Ref(s)
Maturity-Onset Diabetes of the Young, Type 2; MODY2 125851 J:88919


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory