Phenotypes Associated with This Genotype

Genotype
MGI:3037922

• Allelic Composition: Egfr^Vel/Egfr⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

corneal opacity ( J:88776 )

• the eyes of adult heterozygotes exhibit corneal opacity

microphthalmia ( J:88776 )

• the eyes of adult heterozygotes are often small

abnormal eyelid morphology ( J:88776 )

• excessive secretions are always observed at the edges of adult heterozygous mutant eyelids, possibly due to infection, drying, or trauma

abnormal eyelid development ( J:88776 )

• migration of eyelid epithelial cells appears to be defective

failure of eyelid fusion ( J:88776 )

• at E16.5, the upper and lower eyelids of wild-type embryos are fused in the midline, whereas those of heterozygous mutant embryos remain far apart due to defective migration of eyelid epithelial cells

eyelids open at birth ( J:88776 )

• heterozygotes are born with eyelids open, whereas the eyelids of wild-type littermates remain closed until 12 days after birth

cellular

decreased fibroblast cell migration ( J:88776 )

• in vitro, mouse embryonic fibroblasts (MEFs) isolated from heterozygous embryos show ~47% reduction in their migratory ability relative to wild-type MEFs

growth/size/body

weight loss ( J:166602 )

• significant weight loss is observed with addition of 2% dextran sodium sulfate (DSS) to water, suggesting susceptibility to induced colitis

integument

plush coat ( J:88776 )

• coats have a velvet-like texture

waved hair ( J:88776 )

• the first coat is wavy

abnormal hair follicle orientation ( J:88776 )

• after the first coat, pelage hair loses its waviness and appears disoriented, with individual shafts projecting in different directions

curly vibrissae ( J:88776 )

• heterozygotes are born with curly vibrissae