Phenotypes Associated with This Genotype

Genotype
MGI:3036842

• Allelic Composition: Glp1r^tm1Ddr/Glp1r^tm1Ddr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas secretion ( J:88159 )

• blunted first phase of insulin secretion

• blunted second phase of insulin secretion

homeostasis/metabolism

increased circulating glucose level ( J:88159 )

• in response to oral glucose consumption observed in both males and females relative to wild-type controls

• observed in female mice, but not male mice, following intraperitoneal glucose injection

decreased circulating insulin level ( J:88159 )

• reduced insulin response to oral glucose consumption observed in both males and females relative to wild-type controls

• following intraperitoneal glucose injection, the first phase insulin secretion was absent

• insulin levels remained reduced 30 minutes later

impaired glucose tolerance ( J:88159 )

• observed in both male and female mice after oral glucose consumption

• observed in female mice, but not male mice, after intraperitoneal glucose injection