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Phenotypes Associated with This Genotype
Genotype
MGI:3036833
Allelic
Composition
Six3tm1Gco/Six3tm1Gco
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Six3tm1Gco mutation (0 available); any Six3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes died at birth

craniofacial
• lacked most structures anterior to the mid brain while the remainder of the body was apparently normal
• eyes and nose missing
• rostral skull and maxillofacial derivatives stunted
• absent at E9.5
• by E8-8.25, optic pits are undetectable

embryo
• anterior patterning is affected by the 1-2 somite stage
• normal thickening in the neurectodermal border is absent

skeleton
• rostral skull and maxillofacial derivatives stunted

nervous system
• normal thickening in the neurectodermal border is absent
• by E8-8.25, forebrain morphogenesis is abnormal
• telencephalic vesicles absent at E12.5
• at E12.5 there was severe truncation of the forebrain
• by E8-8.25 the midbrain appears to be anteriorly expanded

vision/eye
• absent at E12.5
• at E9.5 eyes are lacking

taste/olfaction
• absent at E9.5

respiratory system
• absent at E9.5

Mouse Models of Human Disease
OMIM ID Ref(s)
Holoprosencephaly 2; HPE2 157170 J:81797


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory