Phenotypes Associated with This Genotype

Genotype
MGI:3035910

• Allelic Composition: Smarcb1^tm1Mya/Smarcb1^tm1Mya
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:68501 )

• embryos die between E3.5 and E6.5

embryo

abnormal inner cell mass apoptosis ( J:68501 )

• the ICM stopped growing after 1 day in cultured homozygous embryos and become apoptotic thereafter

increased trophectoderm apoptosis ( J:68501 )

• the trophectoderm did not spread in cultured homozygous embryos and these cells become apoptotic

failure of blastocyst to hatch from the zona pellucida ( J:68501 )

• one third of blastocysts do not hatch from the zona pellucida

reproductive system

failure of embryo implantation ( J:68501 )

♀ • one third of blastocysts do not implant (attach) in vitro

cellular

abnormal inner cell mass apoptosis ( J:68501 )

• the ICM stopped growing after 1 day in cultured homozygous embryos and become apoptotic thereafter

increased trophectoderm apoptosis ( J:68501 )

• the trophectoderm did not spread in cultured homozygous embryos and these cells become apoptotic