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Phenotypes Associated with This Genotype
Genotype
MGI:3034072
Allelic
Composition
Tlr6tm1Aki/Tlr6tm1Aki
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr6tm1Aki mutation (1 available); any Tlr6 mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2)
• normal response of macrophages to lipopeptides of other bacterial origins
• cytokine production by macrophages in response to diacylated (macrophage activating lipopeptide 2 kD [MALP-2]), but not to tiracylated, lipopeptides is completely abrogated
• macrophages produce no NO and IL-12 in response to MALP-2 together with IFN-gamma
• MEFs treated with MALP-2 fail to produce IL-6
• macrophages produce no TNF-alpha in response to MALP-2
• macrophages show impaired TNF-alpha production in response to heat-killed mycoplasma

hematopoietic system
• macrophages are unresponsive to macrophage activating lipopeptide 2 kD (MALP-2)
• normal response of macrophages to lipopeptides of other bacterial origins


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory