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Phenotypes Associated with This Genotype
Genotype
MGI:3033935
Allelic
Composition
Vsx1tm2Mci/Vsx1tm2Mci
Genetic
Background
either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsx1tm2Mci mutation (1 available); any Vsx1 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no corneal defects are observed, either grossly or histologically
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers
• reduced b-wave amplitude in response to white flashes
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells

nervous system
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers

behavior/neurological
N
• no overt behavioral or neurological phenotypes observed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory