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Phenotypes Associated with This Genotype
Genotype
MGI:3033934
Allelic
Composition
Vsx1tm1Mci/Vsx1tm1Mci
Genetic
Background
either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * Black Swiss)
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phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no corneal defects were observed, either grossly or histologically (J:88182)
• no corneal defects were observed, either grossly or histologically (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)
• reduced b-wave amplitude in response to white flashes (J:88182)
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells (J:88182)
• reduced b-wave amplitude in response to white flashes (J:88182)
• putatively associated with incomplete differentiation and function of OFF cone bipolar cells (J:88182)

nervous system
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)
• incomplete terminal differentiation of OFF-cone bipolar cells in the retina as indicated by a reduction in expression of several markers (J:88182)

behavior/neurological
N
• no overt behavioral or neurological phenotypes observed (J:88182)
• no overt behavioral or neurological phenotypes observed (J:88182)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Keratoconus 1; KTCN1 148300 J:88182


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory