Phenotypes Associated with This Genotype

Genotype
MGI:3033402

• Allelic Composition: Bub1b^{Gt(neo-btk)1Dai}/Bub1b^{Gt(neo-btk)1Dai}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:88223 )

• embryos die due to extensive apoptosis during early gestation, failing to survive beyond E8.5

• at E6.5, embryos either have developed abnormally or are resorbed

cellular

increased embryonic tissue cell apoptosis ( J:88223 )

• extensive apoptosis in embryos at E8.5

embryo

increased embryonic tissue cell apoptosis ( J:88223 )

• extensive apoptosis in embryos at E8.5

abnormal blastocyst morphology ( J:88223 )

• E3.5 blastocysts cultured in vitro fail to exhibit robust proliferation and become atrophic by the equivalent of E6.5