mortality/aging
• surviving females died 30 to 35 days after birth, often exhibiting bone fractures
|
• homozygous females were not obtained in generations F1 to F3, but were obtained in generations F4 to F6
|
behavior/neurological
• female mice exhibited impaired mobility consistent with muscle weakness
|
homeostasis/metabolism
renal/urinary system
reproductive system
• crosses involving homozygous females yielded small litters
|
skeleton
• mineral content reduced 40%
|
• bone mineral density reduced 25% to 30%
|
nervous system
hydrocephaly
(
J:78606
)
• observed in some female mice
|