About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3032447
Allelic
Composition
Slc22a5jvs/Slc22a5jvs
Genetic
Background
C3.OH-H2o2 Slc22a5jvs
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc22a5jvs mutation (0 available); any Slc22a5 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 70% die by 5 weeks of age, remainder grow normally to 3 months at least (J:40286)
• 70% die by 5 weeks of age, remainder grow normally to 3 months at least (J:40286)

cardiovascular system
• heart weight/body weight ratio 2X normal (J:13736)
• increased cardiac cell volume (J:13736)
• increased numbers of mitochondria in cardiac cells (J:13736)
• increase in non-collagen protein in cardiac cells (J:13736)
• heart weight/body weight ratio 2X normal (J:13736)
• increased cardiac cell volume (J:13736)
• increased numbers of mitochondria in cardiac cells (J:13736)
• increase in non-collagen protein in cardiac cells (J:13736)
• greater growth in heart weight than normal (J:40286)
• hypertrophy involves ventricles and not atria (J:40286)
• greater growth in heart weight than normal (J:40286)
• hypertrophy involves ventricles and not atria (J:40286)

growth/size/body
• growth was normal through 18 days but retarded by day 28 (J:40286)
• growth was normal through 18 days but retarded by day 28 (J:40286)

homeostasis/metabolism
• lower total serum carnitine levels while body levels as a whole were higher (J:18523)
• lower total serum carnitine levels while body levels as a whole were higher (J:18523)
• increased levels of carnitine in the urine (J:18523)
• increased levels of carnitine in the urine (J:18523)
• result of decreased activity of enzymes in the urea cycle (J:31000)
• result of decreased activity of enzymes in the urea cycle (J:31000)

liver/biliary system
• lipid containing microvesicles in hepatocytes (J:31026)
• lipid containing microvesicles in hepatocytes (J:31026)

renal/urinary system
• increased levels of carnitine in the urine (J:18523)
• increased levels of carnitine in the urine (J:18523)
• lower kidney resorption of carnitine (J:18523)
• lower kidney resorption of carnitine (J:18523)

reproductive system
N
• males that survive beyond 5 weeks of age are fertile although weak (J:14288)
• males that survive beyond 5 weeks of age are fertile although weak (J:14288)
• flexed between the caput and the corpus (J:53598)
• flexed between the caput and the corpus (J:53598)
• proximal corpus swollen due to accumulation of spermatozoa, low columnar and cuboid epithelial cells (J:53598)
• in severe cases, the epithelium ruptures and spermatozoa are extravasated (J:53598)
• distal corpus constricted with no spermatozoa and an accumulation of eosinophilic debris, columnar epithelium (J:53598)
• proximal corpus swollen due to accumulation of spermatozoa, low columnar and cuboid epithelial cells (J:53598)
• in severe cases, the epithelium ruptures and spermatozoa are extravasated (J:53598)
• distal corpus constricted with no spermatozoa and an accumulation of eosinophilic debris, columnar epithelium (J:53598)
(J:53598)
(J:53598)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory