Phenotypes Associated with This Genotype

Genotype
MGI:3029864

• Allelic Composition: Adar^tm2Phs/Adar^tm2Phs
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:87715 )

• death between E11.5 and E12.5

embryo

embryonic growth retardation ( J:87715 )

• slightly retarded development prior to death around E12

hematopoietic system

absent common myeloid progenitor cells ( J:87715 )

• reduced in the fetal liver

impaired hematopoiesis ( J:87715 )

• cell numbers in mutant embryonic hematopoietic tissues were significantly reduced in the yolk sac (to 52%), fetal liver (to 42%), and peripheral blood (to 63%) compared with control embryos

liver/biliary system

abnormal liver development ( J:87715 )

• disintegrating liver structure with reduced cell density evident at E11.5

• often blood accumulation in pathologically enlarged spaces

small liver ( J:87715 )

• significant size reduction of fetal liver evident at E12

• fetal liver size was normal until E11-E11.25

growth/size/body

embryonic growth retardation ( J:87715 )

• slightly retarded development prior to death around E12