Mouse Genome Informatics
hm
    Slc2a2tm1Thor/Slc2a2tm1Thor
involves: 129P2/OlaHsd * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• died at 2-3 weeks of age

endocrine/exocrine glands
• volume density increased 50% as glucagon expression increased
• volume density of beta cells decreased 30%
• pancreas weight dropped about 25% by day 15

growth/size/body
• growth was normal for first 6 days
• failed to thrive thereafter
• body weight down 35% by day 15

homeostasis/metabolism
• blood osmolality increased to 420 mosmol/l
• moderately hyperglycemic at day 15
• glucagons levels were markedly increased at 15 days of age
• relatively hypoinsulinemic at day 15
• glucose stimulated insulin secretion did not occur
• no buildup of insulin mRNA in beta cells
• in an oral glucose tolerance test, a sharp rise in glucose occurred
• hyperglycemia persisted longer than in controls
• basal glucose levels were elevated

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:43839