Phenotypes Associated with This Genotype

Genotype
MGI:3029315

• Allelic Composition: Sp7^tm1Crm/Sp7^tm1Crm
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:74344 )

• animals die within 15 minutes of birth

homeostasis/metabolism

cyanosis ( J:74344 )

• animals rapidly become cyanotic after birth

limbs/digits/tail

abnormal limb morphology ( J:74344 )

• mice exhibit a severe inward bending of the limbs

respiratory system

respiratory distress ( J:74344 )

• animals exhibit difficulty in breathing after birth

skeleton

clavicle hypoplasia ( J:74344 )

abnormal axial skeleton morphology ( J:74344 )

abnormal rib morphology ( J:74344 )

• ribs are often bent and deformed

abnormal vertebrae morphology ( J:74344 )

• vertebrae are often bent and deformed

abnormal bone mineralization ( J:74344 )

• no mineralization is detectable in various bones of E15.5 embryos; bone trabeculae are frequently absent and mesenchymal cells are present at these locations