Phenotypes Associated with This Genotype

Genotype
MGI:3029211

• Allelic Composition: Pck1^tm1.1Mgn/Pck1^tm1.1Mgn; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating free fatty acids level ( J:63929 )

increased circulating triglyceride level ( J:63929 )

decreased liver glycogen level ( J:63929 )

• hepatic glycogen content was decreased at birth, reduced in older mutant animals and was depleted after a 24 hour fast

increased liver triglyceride level ( J:63929 )

• hepatic triglyceride levels were increased by 94% after a 24 hour fast

liver/biliary system

enlarged liver ( J:63929 )

• after a 24 hour fast, the liver mass was increased by 71% over controls

increased liver weight ( J:63929 )

• liver weight was increased by 18%

decreased liver glycogen level ( J:63929 )

• hepatic glycogen content was decreased at birth, reduced in older mutant animals and was depleted after a 24 hour fast

increased liver triglyceride level ( J:63929 )

• hepatic triglyceride levels were increased by 94% after a 24 hour fast

pale liver ( J:63929 )

growth/size/body

enlarged liver ( J:63929 )

• after a 24 hour fast, the liver mass was increased by 71% over controls

increased liver weight ( J:63929 )

• liver weight was increased by 18%