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Phenotypes Associated with This Genotype
Genotype
MGI:3029167
Allelic
Composition
Tgm1tm1Kfyn/Tgm1tm1Kfyn
Genetic
Background
involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm1tm1Kfyn mutation (0 available); any Tgm1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Epidermal abnormalities in Tgm1tm1Kfyn/Tgm1tm1Kfyn mice

mortality/aging
• death within 4 - 5 hours after birth

behavior/neurological
• neonates did not eat
• neonates failed to suckle
• neonates less active than littermate controls

growth/size/body
• neonates substantially smaller than littermate controls
• neonates had lower body weight than littermate controls

homeostasis/metabolism
• progressive dehydration after birth, with death within 4 - 5 hours after birth

integument
• unclear boundary between statum corneum and stratum granulosum

Mouse Models of Human Disease
OMIM ID Ref(s)
Ichthyosis, Congenital, Autosomal Recessive 1; ARCI1 242300 J:45653 , J:74334


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory