Mouse Genome Informatics
hm
    Tgm1tm1Kfyn/Tgm1tm1Kfyn
involves: 129S1/SvImJ * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Epidermal abnormalities in Tgm1tm1Kfyn/Tgm1tm1Kfyn mice

mortality/aging
• death within 4 - 5 hours after birth

behavior/neurological
• neonates did not eat
• neonates failed to suckle
• neonates less active than littermate controls

growth/size
• neonates substantially smaller than littermate controls
• neonates had lower body weight than littermate controls

homeostasis/metabolism
• progressive dehydration after birth, with death within 4 - 5 hours after birth

integument
• unclear boundary between statum corneum and stratum granulosum

Mouse Models of Human Disease
OMIM IDRef(s)
Ichthyosis, Congenital, Autosomal Recessive 1; ARCI1 242300 J:45653 , J:74334