Phenotypes Associated with This Genotype

Genotype
MGI:3029012

• Allelic Composition: Smarcc1^tm1Rhs/Smarcc1⁺
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal embryonic neuroepithelial layer differentiation ( J:72635 )

• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region

abnormal forebrain morphology ( J:72635 )

• extensive malformations in embryos exhibiting exencephaly; expansion of the corpus striatum mediale

abnormal diencephalon morphology ( J:72635 )

• described as malformed

abnormal third ventricle morphology ( J:72635 )

• open third ventricle

abnormal telencephalon morphology ( J:72635 )

• epithelia were located below the thalamus; ganglionic eminence appeared rotated towards the midline

abnormal lateral ventricle morphology ( J:72635 )

• stenosis apparent

exencephaly ( J:72635 )

• 20% of heterozygous embryos exhibit exencephaly

embryo

abnormal neural fold elevation formation ( J:72635 )

• in some embryos exhibit failure of neural fold elevation resulting in failure of neural plate closing and an abnormal brain structure

abnormal embryonic neuroepithelial layer differentiation ( J:72635 )

• ectopic proliferating and differentiating cells were noted in the upper posterior region, and the cells were reduced in number in the telencephalic striatum region