Phenotypes for Dmc1 MGI:3028977 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmc1^tm1Tkm/Dmc1^tm1Tkm
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1^tm1Tkm mutation (0 available); any Dmc1 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

absent ovarian follicles ( J:47307 )

small ovary ( J:47307 )

small testis ( J:47307 )

abnormal gametogenesis ( J:47307 )

abnormal oogenesis ( J:47307 )

absent oocytes ( J:47307 )

abnormal spermatogenesis ( J:47307 )

• spermatocyte apoptosis following arrest during prophase of meiosis I at the zygotene stage

azoospermia ( J:47307 )

arrest of male meiosis ( J:47307 )

• arrest during prophase of meiosis I at the zygotene stage, followed by apoptosis

• defects in chromosome pairing

infertility ( J:47307 )

male infertility ( J:47307 )

endocrine/exocrine glands

absent ovarian follicles ( J:47307 )

small ovary ( J:47307 )

small testis ( J:47307 )

cellular

absent oocytes ( J:47307 )

azoospermia ( J:47307 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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