Phenotypes Associated with This Genotype

Genotype
MGI:3028956

• Allelic Composition: Tead1^Gt(ROSA5)Sor/Tead1^Gt(ROSA5)Sor
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:20882 )

• at E11.5 about half of embryos were necrotic or undergoing resorption

• at E12.5 no viable homozygotes were present

• no homozygous pups were born

cardiovascular system

abnormal heart morphology ( J:20882 )

• tissue edema

• at E11.5 pericardial cavity was dilated

abnormal heart ventricle morphology ( J:20882 )

trabecula carnea hypoplasia ( J:20882 )

• only 1-2 layers of trabeculae as opposed to 3-4 layers normally

thin ventricular wall ( J:20882 )

decreased heart rate ( J:20882 )

• reduced and weak heart rate at E11.5

muscle

trabecula carnea hypoplasia ( J:20882 )

• only 1-2 layers of trabeculae as opposed to 3-4 layers normally

nervous system

abnormal fourth ventricle morphology ( J:20882 )

enlarged fourth ventricle ( J:20882 )

• at E11.5 the 4th ventricle of the brain was enlarged

embryo

pale yolk sac ( J:20882 )

• yolk sacs of E10.5 embryos were pale even though the vascular system was present