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Phenotypes Associated with This Genotype
Genotype
MGI:3028851
Allelic
Composition
Tg(aP2-SREBF1c)9884Reh/0
Genetic
Background
involves: C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(aP2-SREBF1c)9884Reh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• ~20% of mice fail to thrive and die within the first 3 weeks of life (J:50770)
• ~20% of mice fail to thrive and die within the first 3 weeks of life (J:50770)

growth/size/body
• mice appear slightly runted during the first week of life (J:50770)
• although most mice consuming a chow diet gain weight and reach a similar weight to that of control littermates by P40, a few remain runted throughout life (J:50770)
• mice appear slightly runted during the first week of life (J:50770)
• although most mice consuming a chow diet gain weight and reach a similar weight to that of control littermates by P40, a few remain runted throughout life (J:50770)
• during the first week of life mice exhibit a distended abdomen due to liver enlargement (J:50770)
• during the first week of life mice exhibit a distended abdomen due to liver enlargement (J:50770)

adipose tissue
N
• despite adipose tissue defects, adipogenesis is normal in embryonic fibroblasts (J:125992)
• despite adipose tissue defects, adipogenesis is normal in embryonic fibroblasts (J:125992)
• brown fat is hypertrophic and contains fat-laden cells that resemble immature white fat (J:50770)
• brown fat is hypertrophic and contains fat-laden cells that resemble immature white fat (J:50770)
• at P7, mice display enlarged interscapular and submandibular brown fat depots relative to control mice (J:50770)
• at P7, mice display enlarged interscapular and submandibular brown fat depots relative to control mice (J:50770)
• at P8, the cytoplasm of mutant brown adipocytes displays large unilocular vacuoles similar to those of immature white adipocytes but unlike the small multilocular vacuoles observed in wild-type brown adipocytes (J:50770)
• at P8, the cytoplasm of mutant brown adipocytes displays large unilocular vacuoles similar to those of immature white adipocytes but unlike the small multilocular vacuoles observed in wild-type brown adipocytes (J:50770)
• at P40, most mutant brown adipocytes contain a prominent unilocular fat droplet (J:50770)
• at P40, most mutant brown adipocytes contain a prominent unilocular fat droplet (J:50770)
• at P8, mutant brown adipocytes are dramatically enlarged and stain palely (J:50770)
• at P40, most mutant brown adipocytes remain significantly enlarged (J:50770)
• at P8, mutant brown adipocytes are dramatically enlarged and stain palely (J:50770)
• at P40, most mutant brown adipocytes remain significantly enlarged (J:50770)
• at P8, the mutant epididymal fat pad consists predominantly of small immature adipocytes with brightly eosinophilic cytoplasm and a distinct unilocular vacuole (J:50770)
• at P40, the mutant epididymal white fat contains a mixture of mature and immature adipocytes with significant size heterogeneity; immature adipocytes with bright eosinophilic cytoplasm, a round nucleus, and a distinct unilocular vacuole are observed (J:50770)
• at P40, some epididymal fat pads exhibit histological evidence of mild inflammation and fibrosis (J:50770)
• at P8, the mutant epididymal fat pad consists predominantly of small immature adipocytes with brightly eosinophilic cytoplasm and a distinct unilocular vacuole (J:50770)
• at P40, the mutant epididymal white fat contains a mixture of mature and immature adipocytes with significant size heterogeneity; immature adipocytes with bright eosinophilic cytoplasm, a round nucleus, and a distinct unilocular vacuole are observed (J:50770)
• at P40, some epididymal fat pads exhibit histological evidence of mild inflammation and fibrosis (J:50770)
• at 12 weeks of age, the mutant epididymal fat pad weighs only ~35% of the wild-type fat pad (160 mg versus 510 mg, respectively) (J:50770)
• at 12 weeks of age, the mutant epididymal fat pad weighs only ~35% of the wild-type fat pad (160 mg versus 510 mg, respectively) (J:50770)
• at P7, all mice exhibit enlarged interscapular brown fat pads, manifested as bilobed interscapular humps (J:50770)
• at 7-12 weeks of age, mutant interscapular fat pads appear significantly enlarged, very firm, and white (J:50770)
• at P40, mutant interscapular brown fat consists of enlarged adipocytes containing large unilocular fat droplets; the interstitium shows signs of mild chronic inflammation (J:50770)
• at P7, all mice exhibit enlarged interscapular brown fat pads, manifested as bilobed interscapular humps (J:50770)
• at 7-12 weeks of age, mutant interscapular fat pads appear significantly enlarged, very firm, and white (J:50770)
• at P40, mutant interscapular brown fat consists of enlarged adipocytes containing large unilocular fat droplets; the interstitium shows signs of mild chronic inflammation (J:50770)
• at 12 weeks of age, mutant interscapular fat weighs nearly twice as much as wild-type (110 mg versus 58 mg, respectively) (J:50770)
• at 12 weeks of age, mutant interscapular fat weighs nearly twice as much as wild-type (110 mg versus 58 mg, respectively) (J:50770)
• white fat fails to differentiate fully, and the size of white fat depots is significantly reduced (J:50770)
• white fat fails to differentiate fully, and the size of white fat depots is significantly reduced (J:50770)
• at 7-12 weeks of age, mutant white adipose tissue is atrophic (J:50770)
• at P40, epididymal, omental and perinephric white fat deposits are significantly reduced (J:50770)
• at 7-12 weeks of age, mutant white adipose tissue is atrophic (J:50770)
• at P40, epididymal, omental and perinephric white fat deposits are significantly reduced (J:50770)

homeostasis/metabolism
• mice exhibit a significant increase in nonfasting plasma glucose levels, with a mean value 305 mg/dl (J:50770)
• mice exhibit a significant increase in nonfasting plasma glucose levels, with a mean value 305 mg/dl (J:50770)
• mice exhibit a 60-fold increase in nonfasting plasma insulin levels relative to control littermates (J:50770)
• mice exhibit a 60-fold increase in nonfasting plasma insulin levels relative to control littermates (J:50770)
• at 7 weeks of age, plasma cholesterol levels are mildly, but significantly, increased (J:50770)
• at 7 weeks of age, plasma cholesterol levels are mildly, but significantly, increased (J:50770)
• at 7 weeks of age, plasma triglyceride levels are mildly, but significantly, increased (J:50770)
• at 9-11 months of age, plasma triglyceride levels are significantly higher (mean of 450 mg/dl; range, 367-565) than those of control littermates (mean of 97 mg/dl; range, 75-147) (J:50770)
• at 7 weeks of age, plasma triglyceride levels are mildly, but significantly, increased (J:50770)
• at 9-11 months of age, plasma triglyceride levels are significantly higher (mean of 450 mg/dl; range, 367-565) than those of control littermates (mean of 97 mg/dl; range, 75-147) (J:50770)
• all mice are significantly resistant to the glucose-lowering effect of exogenous insulin (J:50770)
• however, there is no evidence for insulin resistance in skeletal muscle (J:50770)
• all mice are significantly resistant to the glucose-lowering effect of exogenous insulin (J:50770)
• however, there is no evidence for insulin resistance in skeletal muscle (J:50770)
• at 7 weeks of age, the hepatic content of triglycerides is significantly increased (J:50770)
• at 7 weeks of age, the hepatic content of triglycerides is significantly increased (J:50770)

liver/biliary system
• at 7 weeks of age, the hepatic content of triglycerides is significantly increased (J:50770)
• at 7 weeks of age, the hepatic content of triglycerides is significantly increased (J:50770)
• at P8, mutant livers display uniform vacuolar changes throughout the hepatic lobule (J:50770)
• at P8, mutant livers display uniform vacuolar changes throughout the hepatic lobule (J:50770)
• at P8, mutant hepatocytes are dramatically swollen; the cytoplasm stains palely eosinophilic and contains numerous microvesicular vacuoles which, in rare cases, coalesce to form a unilocular vacuole that displaces the nucleus peripherally (J:50770)
• at P40, hepatocellular swelling is less severe than at P8, and it is confined to the centrolobular zone; no hepatitis or fibrosis is observed (J:50770)
• at P8, mutant hepatocytes are dramatically swollen; the cytoplasm stains palely eosinophilic and contains numerous microvesicular vacuoles which, in rare cases, coalesce to form a unilocular vacuole that displaces the nucleus peripherally (J:50770)
• at P40, hepatocellular swelling is less severe than at P8, and it is confined to the centrolobular zone; no hepatitis or fibrosis is observed (J:50770)
• at P7, mutant livers are massively enlarged (J:50770)
• mutant livers remain enlarged at 7-12 weeks of age (J:50770)
• at P7, mutant livers are massively enlarged (J:50770)
• mutant livers remain enlarged at 7-12 weeks of age (J:50770)
• at 12 weeks of age, mutant liver weighs twice as much as wild-type liver (3.9 g versus 1.5 g, respectively) (J:50770)
• at 12 weeks of age, mutant liver weighs twice as much as wild-type liver (3.9 g versus 1.5 g, respectively) (J:50770)
• as early as P8, mutant livers are overloaded with fat (J:50770)
• despite a markedly fatty liver, plasma levels of albumin, aspartate aminotransferase, and bilirubin remain normal at 7 weeks of age (J:50770)
• as early as P8, mutant livers are overloaded with fat (J:50770)
• despite a markedly fatty liver, plasma levels of albumin, aspartate aminotransferase, and bilirubin remain normal at 7 weeks of age (J:50770)
• at P7, mutant livers are markedly pale (J:50770)
• mutant livers remain pale at 7-12 weeks of age (J:50770)
• at P7, mutant livers are markedly pale (J:50770)
• mutant livers remain pale at 7-12 weeks of age (J:50770)

endocrine/exocrine glands
• at 7-12 weeks of age, mutant pancreata are significantly enlarged (J:50770)
• at 7-12 weeks of age, mutant pancreata are significantly enlarged (J:50770)

hematopoietic system
• at 7-12 weeks of age, mutant spleens are significantly enlarged (J:50770)
• at 7-12 weeks of age, mutant spleens are significantly enlarged (J:50770)

immune system
• at 7-12 weeks of age, mutant spleens are significantly enlarged (J:50770)
• at 7-12 weeks of age, mutant spleens are significantly enlarged (J:50770)
• at 7-12 weeks of age, mutant abdominal lymph nodes are significantly enlarged (J:50770)
• at 7-12 weeks of age, mutant abdominal lymph nodes are significantly enlarged (J:50770)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory