Phenotypes Associated with This Genotype

Genotype
MGI:3028762

• Allelic Composition: Pik3r1^tm1Khn/Pik3r1^tm1Khn
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal fat cell morphology ( J:87598 )

• adipocytes of smaller size, with a lower lipid content

abnormal fat pad morphology ( J:87598 )

• 40% reduction in the weight of the epididymal fat pads

growth/size/body

growth/size/body region phenotype ( J:87598 )

N • growth and weight gain were normal for the first 6 months of life

homeostasis/metabolism

abnormal glucose homeostasis ( J:87598 )

• insulin stimulated uptake in both adipocytes and extensor digitorum longus muscle was increased 2X

• resistant to obesity induced hyperinsulinemia

decreased circulating insulin level ( J:87598 )

• fasting mice with lower insulin levels although glucose levels were normal

increased insulin sensitivity ( J:87598 )

• insulin had a greater affect on blood glucose levels in an insulin tolerance test although glucose tolerance tests were normal

abnormal lipid homeostasis ( J:87598 )

• basal lipogenesis levels in adipocytes were lower

• more robust incorporation of glucose into lactate

decreased triglyceride level ( J:87598 )

• 25% reduction in body triglyceride levels