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Phenotypes Associated with This Genotype
Genotype
MGI:3028422
Allelic
Composition
Wastm1Kas/Wastm1Kas
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wastm1Kas mutation (0 available); any Was mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymus particularly affected
• about one quarter the normal number of thymocytes
• platelet count reduced to 40% of normal
• B220+. sIgM+ B cells reduced about 50%
• CD4+ and CD8+ cells reduced 50%
• severely reduced numbers of double positive thymocytes

immune system
• thymus particularly affected
• about one quarter the normal number of thymocytes
• B220+. sIgM+ B cells reduced about 50%
• CD4+ and CD8+ cells reduced 50%
• severely reduced numbers of double positive thymocytes
• lymphocyte cellularity reduced in all lymph organs

endocrine/exocrine glands
• thymus particularly affected
• about one quarter the normal number of thymocytes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/09/2024
MGI 6.23
The Jackson Laboratory