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Phenotypes Associated with This Genotype
Genotype
MGI:3027496
Allelic
Composition
Htr4tm1Comp/Htr4tm1Comp
Genetic
Background
129/Sv-Htr4tm1Comp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr4tm1Comp mutation (0 available); any Htr4 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 18% of homozygotes are derived from heterozygous intercrosses over a 3-year period, indicating a small deviation from the expected Mendelian ratio

behavior/neurological
• homozygotes are hypersensitive to pentamethylenetetrazol (PTZ)-induced seizures, showing a higher number of deaths at 60 min post-treatment as well as reduced latency to both death and tonic seizure relative to wild-type controls
• homozygotes are less reactive to novelty-induced locomotion in the open field than wild-type controls, showing an overall 45% decrease in traveled path length on day 1 (but not day 2 or 3) of exposure in both the periphery and center of the open field
• however, no differences in home cage locomotor activity or motor coordination (rotarod test) are observed
• homozygotes show an attenuated response to stress-induced hypophagia relative to wild-type controls (-19.6% vs -36.4%, respectively), exhibiting a +24% increase in food intake during the first 24 hrs after an acute restraint stress (no food/water for 110 min) but resuming normal (baseline) consumption levels at 48 hrs after stress (J:87451)
• whether fed or food-deprived, BIMU8-treated mice fail to exhibit reduced food intake unlike in wild-type mice (J:125754)
• MDMA treated mice fail to exhibit a suppression in appetite unlike wild-type mice (J:125754)
• homozygotes spend significantly less time in the center of an open field during day 1 and 2 (but not day 3) of exposure than wild-type controls, suggesting a slight hyperanxiety-like behavior

nervous system
• homozygotes are hypersensitive to pentamethylenetetrazol (PTZ)-induced seizures, showing a higher number of deaths at 60 min post-treatment as well as reduced latency to both death and tonic seizure relative to wild-type controls

growth/size/body
N
• at 4 months of age, homozygotes display normal baseline eating and drinking behavior in their home cages (J:87451)
• no differences in social behavior, aggression, or sleep are observed relative to age-matched controls (J:87451)
• mice exhibit normal body weight after 3 days of habituation or 24 h food deprivation (J:125754)
• unlike wild-type controls, homozygotes fail to display a significant body weight loss during the first 4 days of recovery from an acute restraint stress
• however, no difference in body weight is observed between unrestrained wild-type and mutant mice during development or at 4 months of age

adipose tissue
• after restraint stress, homozygotes display a lower white adipose tissue weight/body weight ratio than wild-type controls (-38%), with no difference in their total body weight

homeostasis/metabolism
N
• no difference in corticosterone levels is noted between wild-type and mutant mice before or after the elevated plus maze
• normal metabolic parameters (feces, urine) are observed at 4 months of age
• whether fed or food-deprived, BIMU8-treated mice fail to exhibit reduced food intake unlike in wild-type mice
• MDMA treated mice fail to exhibit a suppression in appetite unlike wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
anorexia nervosa DOID:8689 J:125754


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory