Mouse Genome Informatics
hm
    Pklrchar4/Pklrchar4
involves: A/J * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• in mice infected with malaria parasite P. chabaudi

hematopoietic system
• constitutive erythropoeisis resulting from hemolytic anemia due to pyruvate kinase deficiency
• less severe than in Pklrchar4 homozygotes
• resulting from hemolytic anemia due to pyruvate kinase deficiency (J:86735)
• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency

immune system
• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency
• resistance to malaria infection has been observed in congenic strains carrying malaria susceptibility alleles for 2 other QTL (J:86735)
• an inverse relationship exists between malarial parasite load and reticulocyte count (J:86735)
• mice infected with the malaria parasite Plasmodium chabaudi AS exhibit lower parasitemia and no mortality unlike control mice (J:141722)
• in mice infected with malaria parasite P. chabaudi

Mouse Models of Human Disease
OMIM IDRef(s)
Malaria, Susceptibility to 611162 J:86735 , J:141722