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Phenotypes Associated with This Genotype
Genotype
MGI:3027071
Allelic
Composition
Pklrchar4/Pklrchar4
Genetic
Background
involves: A/J * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pklrchar4 mutation (0 available); any Pklr mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• in mice infected with malaria parasite P. chabaudi

hematopoietic system
• less severe than in Pklrchar4 homozygotes
• constitutive erythropoeisis resulting from hemolytic anemia due to pyruvate kinase deficiency
• resulting from hemolytic anemia due to pyruvate kinase deficiency (J:86735)
• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency

immune system
• splenomegaly resulting from hemolytic anemia due to pyruvate kinase deficiency
• resistance to malaria infection has been observed in congenic strains carrying malaria susceptibility alleles for 2 other QTL (J:86735)
• an inverse relationship exists between malarial parasite load and reticulocyte count (J:86735)
• mice infected with the malaria parasite Plasmodium chabaudi AS exhibit lower parasitemia and no mortality unlike control mice (J:141722)
• in mice infected with malaria parasite P. chabaudi

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
malaria DOID:12365 OMIM:609148
OMIM:611162
J:86735 , J:141722


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory